The cyanoacrylate embolization (CAE) technique for chronic venous disease treatment is less painful and leads to a faster recovery than conventional endovenous thermal treatment.According to the instructions for use (IFU) of the VenaSeal closure system (Medtronic), a click here representative CAE product, it has only been approved for treating saphenous veins, not non-saphenous veins.Here, we report a case of ignoring the VenaSeal IFU for treating testicular pain using CAE for non-saphenous veins within the abdominal wall, which is a baseless and non-scientific approach nearing malpractice.Hence, it is imperative for physicians to rigorously read more adhere to the IFU and abstain from experimenting with new treatment methods solely based on personal experience.